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Clinical Trials

Clinical Trials Overview 

Below is a list of currently enrolling Clinical Trials at the Appalachian Clinical and Translational Science Institute (ACTSI). If you would like additional information about a specific trial, you can call the contact number provided and speak with a study coordinator.

Additional information about each trial can be obtained at ClinicalTrials.gov by clicking on the descriptions below

For more information regarding Active Clinical Trials, contact our Medical Director of Clinical Trials - Usha Murughiyan (304) 691-1836.

Active Clinical Trials  
Study ID  PI  Currently Enrolling  Description  Contact Information 
NCT03971071
Ferguson Yes (AMGEN) A Phase 4, Randomized, Double-blind, Placebo-controlled, Parallel-group Study to Evaluate the Efficacy and Safety of Erenumab in Adults With Chronic Migraine and Medication Overuse Headache Daniell Gallagher
NCT03012776 Phan  Yes (TOPS IDE) A Clinical Study to Assess the Safety and Effectiveness of the Premia Spine TOPS™ System. Daniell Gallagher 
NCT04032093 Keblawi No (Matisse) A Phase 2B Placebo-Controlled, Randomized Study of a Respiratory Syncytial Virus (RSV) Vaccine in Pregnant Women   Hillary Salava
NCT03926130 Sundaram  Yes (VIVID-1 AMAM) A Phase 3, Multicenter, Randomized, Double-Blind, Placebo- and Active-Controlled, Treat-Through Study to Evaluate the Efficacy and Safety of Mirikizumab in Patients with Moderately to Severely Active Crohn's Disease Nicole Finley 
NCT04329780 Nease No A Retrospective Multicenter Comparison of Laparoscopic and Robotic-Assisted Roux-en-Y Gastric Bypass and Sleeve Gastrectomy (Retro Bariatric) Daniell Gallagher
NCT04140305 Ferguson  Yes (ENLIGHTEN) A Multicenter, Longitudinal, Open-Label, Single-Arm Study Describing Cognitive Processing Speed Changes in Relapsing Multiple Sclerosis Subjects Treated with Ozanimod David Coates
NCT04173273 Sundaram  Yes  (CULTIVATE) Study Evaluating the Efficacy and Safety of Oral Etrasimod in the Treatment of Adult Participants With Moderately to Severely Active Crohn's Disease Nicole Finley 
NCT03616821 Sundaram Yes [EXPEDITION] An Active and Placebo-Controlled Study of Brazikumab in Participants With Moderately to Severely Active Ulcerative Colitis Nicole Finley
NCT03537508 Shields  No (MET 42) Immunogenicity and Safety of a Quadrivalent Meningococcal Conjugate Vaccine When Administered Concomitantly With Routine Pediatric Vaccines in Healthy Infants and Toddlers in the US  Gina Finley
NCT03759288 Sundaram Yes (Intrepid) An Active and Placebo-Controlled Study of Brazikumab in Participants With Moderately to Severely Active Crohn's Disease  Nicole Finley
NCT04396236 Lopez Yes (PIONEER-PEDS1) A Study of Lasmiditan (LY573144) Treatment in Children Aged 6 to 17 With Migraine  David Coates
NCT04396574 Lopez Yes (PIONEER-PEDS2) A 12-Month Study of Lasmiditan (LY573144) Treatment in Children Aged 6 to 17 With Migraine David Coates
NCT04506190 Nease Yes (ISI-dVBAR-002) A Prospective Multicenter Study to Evaluate the Perioperative Outcomes of Laparoscopic and Robotic-assisted Revisional Bariatric Surgery Daniell Gallagher
Protocol I5Q-MC-B004 Ferguson Yes (TRIUMPH) Preventive Treatment of migraine: Outcomes for Patients in real-world Healthcare systems Daniell Gallagher
TP-201920 Gentile  Yes (Trauma Screw) An Observational Study to Gather Real-World Data on the Tyber Medical Trauma Screw System Daniell Gallagher
P255-501 Lopez Yes (ROAR) A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Phase 4 Study to Evaluate the Efficacy and Safety of Qudexy® XR in the Prevention of Migraine in Children 6 to 11 Years of Age David Coates
NCT04320940 Massey Yes A Randomized, Double-Blind, Controlled Study to Assess the Efficacy and Safety of Intravenous Phenobarbital in Neonatal Seizures Gina Finley
N/A Villa Yes (KEEP)An Exploratory, Multicenter, Randomized, Double-Blind Study of Clinical Outcomes, Tolerability, and Safety of 2 Doses of Oral Pantoprazole in Pediatric Participants, Aged 1 to 11 Years and 12 to 17 Years Who Require Maintenance Therapy for Healed Erosive Esophagitis David Coates
NTC04938830 Shields Yes A Phase 3, Multicenter, Randomized, Partially Blinded, Palivizumab- Controlled Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of MK-1654 in Infants and Children at Increased Risk for Severe RSV Disease Gina Finley
CLP-001 Webb  Yes (RESET-RA) A Randomized, Sham-Controlled, Double-Blind Study of Vagus Nerve Stimulation for Moderate to Severe Rheumatoid Arthritis Daniell Gallagher

Updated on February 22, 2022.

For more information on PI Initiated Clinical Trials, contact our Medical Director of Clinical Trials - Usha Murughiyan (304) 691-1836

PI Initiated Clinical Trials  
IRB Number  PI  Description 
GRANT  Sundaram, Uma  NIH COBRE
GRANT  Sundaram, Uma NIH Ro1
GRANT  Sundaram,  Uma  Ro1NET
499630 Koester, Alan AVANTA (SRTMMCP)
463451 Koester, Alan AVANTA (SRTMPIP)
964144 Sundaram, Uma Regulation of intestinal nutrient and electrolyte transport in chronic diseases.
1632953 Sundaram, Uma Activated Charcoal COVID-19

Updated on April 20, 2021.