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Clinical and Translational Sciences

Clinical and Translational Sciences

The Department of Clinical and Translational Sciences (DCTS) was created to foster collaboration and enrichment among clinicians and basic scientists. Permanent and joint-faculty work together within an integrated structure to advance research and therapy options for Central Appalachia.

DCTS is the academic home for the Appalachian Clinical Translational Science Institute (ACTSI) at Marshall University, the Marshall Clinical Research Center and Marshall Informatics that provides support and resources to researchers, clinicians and patient advocates working to improve the health of the people of Appalachia. This multidisciplinary department leverages a variety of expertise to address issues through the full spectrum of translational science.

Subha Arthur, PhD
Assistant Professor

Alipe Borthakur
Assistant Professor 

Shelvy L. Campbell
Assistant Dean of Diversity

Alfred A. Cecchetti, PhD, MSc, MSc IS
Director, Division of Clinical Informatics (DCI)

Todd Gress, MD, MPH
Assistant Dean & Director Clinical Research

Jennifer Haynes
Research Assistant Professor 

Isabel Larre', PhD
Assistant Professor, DCTS

Rajan Lamichhane, PhD
Assistant Professor, Bio-statistician 

Balasubramanian Palaniappan, PhD
Assistant Professor 

Soudamani Singh, PhD
Assistant Professor 

Uma Sundaram, MD
Vice Dean, Chairman, DCTS

Yangling Yan, PhD
Assistant Professor

John Crutchley, Ph.D.
Research Instructor 

Amanda Arbaugh
Finance Administrator
arbaugh@marshall.edu
Phone: (304) 691-1844

Marlenea Brand, MPA
Administrative Director of Graduate Studies
Phone: 304-696-7399
brandm@marshall.edu

Kelly Carothers
Assistant Graduate Recruiter
carothers@marshall.edu
Phone: (304) 696-7279

Rong Fan 
Executive Administrative Assistant 
Rong.fan@marshall.edu
Phone: (304) 691-1841 

Marriah Menchaca
Recruitment and Marketing Specialist 
menchacama@marshall.edu
Phone: (304) 696-3365

Marie Murphy
Administrative Assistant
murphyma@marshall.edu
Phone: (304) 696-7278

Catherine Sedergen 
Department Administrator 
sedergrenc@marshall.edu 
Phone: (304) 696-7339

Rachael Wyant
Administrative Assistant to Vice Dean 
wyant18@marshall.edu
Phone: (304) 691-1836

Robin Ashford, Pharm D
Coordinator
(304) 691-1082
ashford@marshall.edu

Kristina Childers
Nurse Practitioner
304-691-6817
kyle5@marshall.edu

Mary Beth Cordle, MS, Quality
Officer
(304) 691-1081
cordlem@marshall.edu

Nicole Finley
Coordinator
finley18@marshall.edu

Linda Morgan, RN
Coordinator
(304) 691-1213
lsmorgan@marshall.edu

Sara Runyon
Coordinator
ross35@marshall.edu

Mallori Scarberry
Coordinator
304-691-5393
walker257@marshall.edu

Scott Wiley, BA
Coordinator
(304) 691-1577
wiley51@marshall.edu

Cecchetti
Alfred Cecchetti, PhD, MSc, MSc IS
Clinical Informatics Data Architect
DCTS

cecchetti@marshall.edu

SchaferGouthami Kothakapu
MSCS
Data Warehouse Research Analyst 

kothakapu@marshall.edu


Rajan Lamichhane, PhD
Assistant Professor, Biostatistician
lamichhaner@marshall.edu

Uma Sundaram, MD
Chairman

Phone: (304) 691-1841
sundaramu@marshall.edu

For a full listing of publications, please access PubMed.

Mast cell regulation of Na-glutamine co-transporters B0AT1 in villus and SN2 in crypt cells during chronic intestinal inflammation. Singh S, Arthur S, Talukder J, Palaniappan B, Coon S, Sundaram U. Biochim Biophys Acta. 2015 April;10.1186/s12876-015-0275-5

Chronic and selective inhibition of basolateral membrane Na-K-ATPase uniquely regulates brush border membrane Na absorption in intestinal epithelial cells.Manoharan P, Gayam S, Arthur S, Palaniappan B, Singh S, Dick GM, Sundaram U. Dig Dis Sci. 2015 April;308(8):C650-6. doi: 10.1152/ajpcell.00355.2014

Molecular mechanism of regulation of villus cell Na-K-ATPase in the chronically inflamed mammalian small intestine. Saha P, Sundaram U, Manoharan P, Arthur S, Kekuda R, et al. Biochimica et biophysica acta. 2015; 1848(2):702-11.


Todd Gress, MD, MPH
Assistant Dean & Director of Clinical Research

Phone: (304) 691-8648
gress@marshall.edu
Click Here to View Biosketch

For a full listing of publications, please access PubMed.

Intrahepatic cholestasis of pregnancy with concomitant hepatitis C virus infection, Joan C. Edwards SOM, Marshall University Belay T, Woldegiorgis H, Rayyan T, Gress T. Eur J Gastroenterol Hepatol.. 2015 Apr;27(4):372-4. doi: 10.1097/MEG.0000000000000293

After-hours pediatric care compared with emergency department care: a retrospective charge analysis Goodrich S, Evans J, Werthammer J, Gress T. Clin Pediatr (Phila).. 2015 Apr;54(4):324-7. doi: 10.1177/0009922815574678

Effects of a Brief Physical Activity Program on Young Students' Physical Fitness. Hayes RM, Thompson LM, Cottrell L, Pino I, Gilkerson, CL, Flesher SL, Gress T. Clin Pediatr (Phila).. 2015 Feb 2. pii: 0009922815569204


Subha Arthur, PhD
Assistant Professor

arthursu@marshall.edu

For a full listing of publications, please access PubMed.

Molecular mechanism of regulation of villus cell Na-K-ATPase in the chronically inflamed mammalian small intestine. Saha P, Manoharan P, Arthur S, Sundaram S, Kekuda R, Sundaram U. Biochim Biophys Acta. 2015;1838(5):1848(2):702-11. PMID:25462166

Chronic and selective inhibition of basolateral membrane Na-K-ATPase uniquely regulates brush border membrane Na absorption in intestinal epithelial cells. Manoharan P, Gayam S, Arthur S, Palaniappan B, Singh S, Dick G, Sundaram U. American journal of physiology Cell physiology. 2015:ajpcell.00355.2014. Epub 2015/02/06. doi: 10.1152/ajpcell.00355.2014. . PMID: 25652450

Mast cell regulation of Na-glutamine co-transporters B0AT1 in villus and SN2 in crypt cells during chronic intestinal inflammation. Singh S, , Arthur S, Talukder J, Palaniappan B, Coon S, et al. BMC gastroenterology 2015; 15:47. PMID: PMC4405831


Isabel Larre', PhD
Assistant Professor

perezm@marshall.edu

For a full listing of publications, please access PubMed.

Ouabain increases gap junctional communication in epithelial cells Ponce A, Larre I, Castillo A, García-Villegas R, Romero A, Flores Maldonado C, Martinez-Rendón J, Contreras RG, Cereijido MCell Physiol Biochem. 2014, ;34:2081-90. PMID:25562156

The emergence of the concept of tight junctions and physiological regulation by ouabain. Larre I, Ponce A, Franco M, Cereijido M. Semin Cell Dev Biol. 2014;36C:149-156. PMID: 25242280

Ouabain induces endocytosis and degradation of tight junction proteins through ERK1/2-dependent pathways. Rincon-Heredia R, Flores-Benitez D, Flores-Maldonado C, Bonilla-Delgado J, García-Hernández V, Verdejo-Torres O, Castillo AM, Larré I, Poot-Hernández AC, Franco M, Gariglio P, Reyes JL, Contreras RG Exp Cell Res. 2013.. PMID: 24140471


Piyali Dasgupta, PhD
dasgupta@marshall.edu

For a full listing of publications, please access PubMed.

Capsaicin induces apoptosis in human small cell lung cancer via the TRPV6 receptor and the calpain pathway Lau, J.K., Brown, K.C., Dom, A.M., Witte, T.R., Thornhill, B.A., Crabtree, C.M., Perry, H.E., Brown, J.M., Ball, J.G., Creel, R.G., Damron, C.L., Rollyson, W.D., Stevenson, C.D., Hardman, W.E., Valentovic, M.A., Carpenter, A.B. and Dasgupta, P.Apoptosis. 19, 1190-201. PMID:24878626

Nicotine induces the upregulation of the alpha7-nicotinic receptor (α7-nAChR) in human squamous cell lung cancer cells via the Sp1/GATA pathway. Brown, K.C., Perry, H. E., Lau, J.K., Jones, D.V., Pulliam, J.F., Thornhill, B.A., Crabtree, C.M., Luo, H., Chen, Y.C. and Dasgupta, P. J. Biol. Chem. 2013;288, 33049-59. PMID: 24089524

Inhibition of cholinergic signaling causes apoptosis in human bronchioalveolar carcinoma. Lau, J.K., Brown, K.C., Thornhill, B.A., Crabtree, C.M., Dom, A.M., Witte, T.R., Hardman, W.E., McNees, C.A., Stover, C.A., Luo, H., Chen, Y.C., Carpenter, A.B., Dasgupta, P. Cancer Research. 2013.73, 4, 1329-1339. PMID: 23222296


Yanling Yan, PhD
Assistant Professor

yan@marshall.edu

For a full listing of publications, please access PubMed.

Involvement of Na/K-ATPase in Hydrogen Peroxide-Induced Activation of Src/ERK Pathway in LLC-PK1 Cells Yu Wang, Qiqi Ye, Changxuan Liu, Jeffrey X Xie, Yanling Yan, Fangfang Lai, Qiming Duan, Xiaomei Li, Jiang Tian, and Zijian Xie.Free Radical Biology & Medicine. 2014, 71: 415-26. PMID:24703895

The involvement of reactive oxygen species in a feed-forward mechanism of Na/K-ATPase mediated signaling transduction. Yanling Yan, Anna P. Shapiro, Steven Haller, Vinai Katragadda, Lijun Liu, Jiang Tian, Venkatesha Basrur, Deepak Malhotra, Zi-jian Xie, Nader G. Abraham, Joseph I. Shapiro, and Jiang Liu. Journal of Biological Chemistry. 2013, 288: 34249-34258. PMID: 24121502

Protein Carbonylation Regulates Renal Proximal Tubular Na/K-ATPase Signaling and Sodium Transport. Yanling Yan, Zi-jian Xie, Joseph I. Shapiro, and Jiang Liu. FASEB J. 2013, 27:231.7. PMID: 21555512


Soudamani Singh
PhD

singhs@marshall.edu

For a full listing of publications, please access PubMed.

Chronic and selective inhibition of basolateral membrane Na-K-ATPase uniquely regulates brush border membrane Na absorption in intestinal epithelial cells Manoharan P, Gayam S, Arthur S, Palaniappan B, Singh S, Dick G, Sundaram U.American Journal of Physiology-Cell Physiology. 2015 00355. PMID:25652450

Mast cell regulation of Na-glutamine co-transporters B0AT1 in villus and SN2 in crypt cells during chronic intestinal inflammation Singh S, Arthur S, Talukder J, Palaniappan B, Coon S, Sundaram UBMC Gastroenterol. 2015 Apr 15;15:47. doi: 10.1186/s12876-015-0275-5

Unique regulation of Na-glutamine cotransporter SN2/SNAT5 in rabbit intestinal crypt cells during chronic enteritis.  Singh S, Arthur S, Sundaram U. J Cell Mol Med. 2018 Mar;22(3):1443-1451. doi: 10.1111/jcmm.13257.

Cyclooxygenase pathway mediates the inhibition of Na-glutamine co-transporter B0AT1 in rabbit villus cells during chronic intestinal inflammation. Arthur S, Singh S, Sundaram U. PLoS One. 2018;13(9):e0203552. doi: 10.1371/journal.pone.0203552.


Maria Serrat, PhD
Serrat@marshall.edu

For a full listing of publications, please access PubMed.

Environmental temperature impact on bone and cartilage growth.
Serrat MA. Compr Physiol. 2014 Apr;4(2):621-55. doi: 10.1002/cphy.c130023.
PMID: 24715562 [PubMed - in process]

Hindlimb heating increases vascular access of large molecules to murine tibial growth plates measured by in vivo multiphoton imaging.
Serrat MA, Efaw ML, Williams RM. J Appl Physiol (1985). 2014 Feb 15;116(4):425-38. doi: 10.1152/japplphysiol.01212.2013. Epub 2013 Dec 26. PMID: 24371019 [PubMed - in process]

Allen’s rule revisited: temperature influences bone elongation during a critical period of postnatal development.
Serrat MA. Anat Rec (Hoboken). 2013 Oct;296(10):1534-45. doi: 10.1002/ar.22763. Epub 2013 Aug 19. PMID: 23956063 [PubMed - indexed for MEDLINE]


Komal Sodhi, MD
sodhi@marshall.edu

For a full listing of publications, please access PubMed.

Agonists of epoxyeicosatrienoic acids reduce infarct size and ameliorate cardiac dysfunction via activation of HO-1 and Wnt1 canonical pathway. Cao J, Tsenovoy PL, Thompson EA, Falck JR, Touchon R, Sodhi K , Rezzani R, Shapiro JI, Abraham NG.Prostaglandins Other Lipid Mediat. 2015 Jan-Mar;116-117:76-86. PMID:25677507

HO-1 Upregulation Attenuates Adipocyte Dysfunction, Obesity, and Isoprostane Levels in Mice Fed High Fructose Diets.. Khitan Z, Harsh M, Sodhi K, Shapiro JI, Abraham NG.J Nutr Metab. 2014;2014:980547. PMID:25295182

CYP2J2 targeting to endothelial cells attenuates adiposity and vascular dysfunction in mice fed a high-fat diet by reprogramming adipocyte phenotype. Abraham NG, Sodhi K, Silvis AM, Vanella L, Favero G, Rezzani R, Lee C, Zeldin DC, Schwartzman ML.Hypertension. 2014 Dec;64(6):1352-61. PMID:25245389


Alfred Cecchetti, PhD, MSc,
MSc IS
Clinical Informatics Data Architect
ACTSI

Phone: (304) 691-1834
cecchetti@marshall.edu

For a full listing of publications, please access PubMed.

Team building: electronic management-clinical translational research (eM-CTR) systems. Cecchetti AA, Parmanto B, Vecchio ML, Ahmad S, Buch S, Zgheib NK, Groark SJ Jr, Vemuganti A, Romkes M, Sciurba F, Donahoe MP, Branch RA.Clin Transl Sci. 2009 Dec;2(6):449-55. PMID:20443940

Family networks of obesity and type 2 diabetes in rural Appalachia. Pancoska P1, Buch S, Cecchetti A, Parmanto B, Vecchio M, Groark S, Paulsen S, Bardwell G, Morton C, Chester A, Branch R. Clin Transl Sci. 2009 Dec;2(6):413-21. PMID:20443933

Feasibility of adolescents to conduct community-based participatory research on obesity and diabetes in rural Appalachia. Bardwell G, Morton C, Chester A, Pancoska P, Buch S, Cecchetti A, Vecchio M, Paulsen S, Groark S, Branch RA. Clin Transl Sci. 2009 Oct;2(5):340-9. PMID:20443917


Balasubramanian Palaniappan
PhD, Coordinator

palianappan@marshall.edu

For a full listing of publications, please access PubMed.

Chronic and selective inhibition of basolateral membrane Na-K-ATPase uniquely regulates brush border membrane Na absorption in intestinal epithelial cells Manoharan, P., Gayam, S., Arthur, S., Palaniappan, B., Singh, S., Dick, G., & Sundaram, U.American Journal of Physiology-Cell Physiology. 2015 00355. PMID:25652450

Antiviral activity of ancient system of ayurvedic medicinal plant Cissus quadrangularis L. (Vitaceae). Balasubramanian, P., Jayalakshmi, K., Vidhya, N., Prasad, R., Khaleefathullah Sheriff, A., Kathiravan, G., Rajagopal, K. and Sripathi M. Sureban. Journal of Basic and Clinical Pharmacy. 2010;1(1): 37-40.

Mast cell regulation of Na-glutamine co-transporters B0AT1 in villus and SN2 in crypt cells during chronic intestinal inflammation. Singh S, Arthur S, Talukder J, Balasubramanian, P., Coon S, et al. BMC gastroenterology. 2015; 15:47