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Jennifer Haynes

Jennifer Haynes, Ph.D.
Research Assistant Professor

Jennifer Haynes, Ph.D., is a Research Assistant Professor in the Department of Clinical and Translational Sciences at Marshall University’s Joan C. Edwards School of Medicine. She received her B.Sc. in Cell Biology and Genetics from the University of British Columbia in Vancouver, Canada, and her Ph.D. in Molecular and Medical Genetics from the University of Toronto in Toronto, Canada. Throughout her training, Dr. Haynes’ primary research focus has been cancer cell biology. Her research projects have been diverse, and include studying conserved cellular processes such as cell cycle, signal transduction, transcriptional regulation, polarity, and cytoskeleton remodeling.

Previously, Dr. Haynes was a Research Associate at the Princess Margaret Cancer Centre in Toronto, Canada, where she investigated new therapeutic strategies for targeting colorectal cancer stem cells. In addition, she established a panel of long-term epithelial organoid cultures from human colorectal cancer tissue, representing different mutation profiles and molecular subtypes. Her current research interests include understanding the molecular mechanisms underlying alterations in nutrient transport in inflammatory bowel disease (IBD) and IBD-related cancer, primarily using three dimensional organoid culture models derived from human small intestine and colon stem cells.

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Recent Publications 

  1. Moderate Alcohol Consumption Uniquely Regulates Sodium-Dependent Glucose Co-Transport in Rat Intestinal Epithelial Cells In Vitro and In Vivo. Butts M, Singh S, Haynes J, Arthur S, Sundaram U. J Nutr2020 Apr 1;150(4):747-755doi: 10.1093/jn/nxz277. 
  2. Moderate Alcohol Consumption Inhibits Sodium-Dependent Glutamine Co-Transport in Rat Intestinal Epithelial Cells in Vitro and Ex Vivo. Butts M, Singh Paulraj R, Haynes J, Arthur S, Singh S, Sundaram U. Nutrients2019 Oct 18;11(10). doi: 10.3390/nu11102516. 
  3. Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells. Lima-Fernandes E, Murison A, da Silva Medina T, Wang Y, Ma A, Leung C, Luciani GM, Haynes J, Pollett A, Zeller C, Duan S, Kreso A, Barsyte-Lovejoy D, Wouters BG, Jin J, Carvalho DD, Lupien M, Arrowsmith CH, O'Brien CA. Nat Commun2019 Mar 29;10(1):1436doi: 10.1038/s41467-019-09309-4. 
  4. A rapid in vitro methodology for simultaneous target discovery and antibody generation against functional cell subpopulations. Nixon AML, Duque A, Yelle N, McLaughlin M, Davoudi S, Pedley NM, Haynes J, Brown KR, Pan J, Hart T, Gilbert PM, Singh SK, O'Brien CA, Sidhu SS, Moffat J. Sci Rep2019 Jan 29;9(1):842. doi: 10.1038/s41598-018-37462-1. PubMed PMID: 30696911; PubMed Central PMCID: PMC6351593.