My principle research focus is to investigate contributions of chronic oxidative stress and metabolic imbalance as it pertains to development of obesity and diabetes with associated long-term complications. In this regard, during the last five years my research with Dr. Abraham focused on physiological and molecular aspects at (dys) regulation of the cellular antioxidant defense system i.e. the heme-heme oxygenase system in association with chronic redox imbalance. Heme oxygenase also serves as the mediator of cross talk between adipose tissue and the vasculature. In this regard, I have studied the impact of adipocyte dysfunction on vascular endothelial integrity through the prism of heme oxygenase.
An equally exciting focus my research entails examining HO-dependent regulation of eicosanoids and their physiological effects, particularly in the vasculature and perivascular adipocytes.
I believe this to be important research that is highly relevant to the pathogenesis of metabolic syndrome. My research projects have been diverse and have encompassed cell culture, animal models, molecular and cell biology and oganotypic cultures.