SundaramJiang Liu, MD, PhD
Associate Professor

Research Interest

My research has focused on the roles of endogenous cardiotonic steroids, oxidative stress, and Na/K-ATPase signaling transduction on renal sodium handling, salt-sensitive hypertension as well as renal/cardiac fibrosis and organ remodeling. Recently, we demonstrated that cardiotonic steroids signaling through the Na/K-ATPase generated ROS is essential for the overall Na/K-ATPase signal transduction, as well as that the Na/K-ATPase α1 subunit and c-Src form a signaling complex under native resting condition. We have also demonstrated the relevance of the Na/K-ATPase signaling mediated oxidant amplification loop to the pathophysiology of renal and cardiovascular diseases and salt sensitivity.