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Denvir, James

James Denvir, PhD
Associate Professor

Phone: (304) 696-7327

Research Interest

Advances in technology, combined with new discoveries at the molecular level, have significantly changed the nature of biomedical research during the past two decades. New tools give investigators the opportunity to perform experiments that generate many millions of data points. Developments in our understanding of molecular mechanisms of gene expression – for example, in actions of microRNA and in epigenetic modification – have both provided new methods of experimental analysis and added to the complexity of our understanding of the molecular basis of biological function. In pursuing the understanding of complex disease, its prevention, and treatment, we typically address several different questions: Are there genetic signatures that predispose individuals to the disease? Are there environmental factors that alter gene expression in such a way as to increase an individual’s risk of disease, and if so, what is the molecular mechanism of this increased risk? Once an individual contracts a disease, what is the mechanism of progression of the disease? The ultimate aims of the research are to use answers to these interrelated questions to develop prognostic tests, interventions, and behavioral modifications to prevent, slow progression of, and treat the disease.

Mitochondrial oxidative phosphorylation is impaired in TALLYHO mice, a new obesity and type 2 diabetes animal model. Hunter CA, Kartal F, Koc ZC, Murphy T, Kim JH, Denvir J, Koc EC. Biochem Cell Biol. 2019 Nov;116:105616. doi: 10.1016/j.biocel.2019.105616. Epub 2019 Sep 19.

mRNA expression data in breast cancers before and after consumption of walnut by women. Elaine Hardman W, Primerano DA, Legenza MT, Morgan J, Fan J, Denvir J. 2019 Aug;25:104050. doi: 10.1016/j.dib.2019.104050. eCollection 2019 Aug.

Dietary walnut altered gene expressions related to tumor growth, survival, and metastasis in breast cancer patients: a pilot clinical trial. Hardman WE, Primerano DA, Legenza MT, Morgan J, Fan J, Denvir J. Nutr Res. 2019 Jun;66:82-94. doi: 10.1016/j.nutres.2019.03.004. Epub 2019 Mar 10.

Cytokine Regulation in Human CD4 T Cells by the Aryl Hydrocarbon Receptor and Gq-Coupled Receptors. McAleer JP, Fan J, Roar B, Primerano DA, Denvir J. Sci Rep. 2018 Jul 19;8(1):10954. doi: 10.1038/s41598-018-29262-4.

Genomic Analysis of Demographic History and Ecological Niche Modeling in the Endangered Sumatran Rhinoceros Dicerorhinus sumatrensis. Mays HL Jr, Hung CM, Shaner PJ, Denvir J, Justice M, Yang SF, Roth TL, Oehler DA, Fan J, Rekulapally S, Primerano DA. Curr Biol. 2018 Jan 8;28(1):70-76.e4. doi: 10.1016/j.cub.2017.11.021. Epub 2017 Dec 14.

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