Sandrine V. Pierre, PhD
Professor
pierres@marshall.edu

Research Statement

How do membrane Na+/K+-ATPases regulate cellular function in health and diseases?

The integrity of Na+/K+-ATPase protein complexes at the cell membrane is critical for the maintenance of cellular ion homeostasis. It is also key to the initiation of specific cellular responses through functional control of subcellular networks. The developmental, physiological, and translational impacts of these emerging mechanisms is an area of active investigation.

We utilize integrated translational omics and genetic approaches in preclinical animal models of chronic diseases and human cells to understand the molecular mechanisms of Na+/K+-ATPase receptor function and develop novel approaches for therapeutic interventions in major renal and cardiovascular diseases.