The Marshall University Medical Center provides a technologically advanced focal point for the clinical teaching, outreach and service programs of the Joan C. Edwards School of Medicine. Opened in 1998, the 185,000-square-foot center is connected to Cabell Huntington Hospital and the Edwards Comprehensive Cancer Center through a shared atrium and multiple connectors.

For patients, the Medical Center offers patients a comprehensive, state of the art medical practice setting where they can conveniently access both primary and specialty care outpatient services. The center houses the main outpatient clinics and clinical education support facilities for a handful of the school's major clinical departments: Family & Community Health, Neuroscience, Obstetrics & Gynecology, Orthopaedics, Pediatrics and Surgery. 

For medical students, resident physicians and fellows in advanced training, the Medical Center provides a cohesive clinical education environment, allowing them to cross specialty lines to follow patients through all stages of care. In addition to a modern health science library and learning center, the center houses the academic and administrative offices of the School of Medicine. 

For the State of West Virginia and the tri state region, Marshall’s Medical Center provides a hub for the School of Medicine's award winning outreach and service programs. Included in the Medical Center complex is the four-story Robert C. Byrd Center for Rural Health, which houses a conference facility for distance learning and support offices for the School of Medicine’s rural health program and rural research activities.