Clinical Research Center

Clinical Research Center


The Mission of the Clinical Research Center (CRC) is to promote clinical and translational research in order to provide advance care that is currently unavailable for the residents of our Tristate Metro Community (West Virginia, Southern Ohio and Eastern Kentucky).  All of our clinical trials adhere to both our vision as well as the guiding principles (below).  We encourage all residents of the Tristate community to visit the website periodically to discover if any clinical trials may be of interest to them or their family. 

The CRC has been organized as a centralized unit within the Office of Research and Graduate Education at Joan C. Edwards School of Medicine (JCESOM).  The centralized CRC better coordinates and promotes all clinical research at JCESOM.  The primary office consists of the Vice Dean for Research and Graduate Education, Medical Director of the CRC, Director of Clinical Informatics and support staff (all listed below).  The CRC is located in the Charles H. McKown Translational Genomic Research Institute at Marshall University Medical Center in Cabell Huntington Hospital.

Guiding Principles

  • Long-term engagement

    Research Investigators are our long-term partners.  The CRC seeks to build a lasting partnership with all of the researchers at the Joan C. Edwards School of Medicine

  • Mutual Benefit

    The CRC understands the role and pressures of being a primary investigator.  It is our goal to enhance the environment, research and reputation of each of our partners.

  • Professionalism

    The Center staff will work together with humility, candor, and mutual respect for expertise and cultural differences when communicating with researchers and community members.

  • Shared Responsibility

    All partners have obligations towards the patients, the project, the community and each other.

  • Integrity

    All decisions and actions will be based on optimizing best-practices, maintaining data integrity, assuring safety, and upholding the highest standards of medical ethics and scientific quality.


We will be a world leader in community academic clinical research supporting medical innovation and care in Appalachia. To realize this vision, we will strive to:

  • develop a new standard for scholarship in clinical research.
  • nurture an environment of collaboration, creativity and professional development throughout the Marshall research community.
  • foster a goal-oriented and balanced approach to research.
  • advance effective strategic alliances.
  • provide access to cutting edge healthcare opportunities to the underserved community.

Uma Sundaram, MD

Vice DeanOffice of Research & Graduate Education
Chairman, Department of Clinical & Translational Science

Amber Deller, RN
(304) 691-1830

Robin Ashford, Pharm D
(304) 691-1082

Lesly Hollon, APRN, FNP-C 
(304) 691-6817

Scott Wiley, BA
(304) 691-1577

Douglas Melton, LPN, FACHE
(304) 691-8618

Linda Morgan, RN
(304) 691-1213

Mary Beth Cordle, MS
Quality Officer
(304) 691-1081

Betina Dingess
Administrative Assistant
(304) 691-1836

Alexis Damron, RN
(304) 691-6859

Clinical Trials

Below is a list of currently enrolling Clinical Trials at the Appalachian Clinical and Translational Science Institute (ACTSI). If you would like additional information about a specific trial, you can call the contact number provided and speak with a study coordinator.

Additional information about each trial can be obtained at by clicking on the descriptions below

Study ID PI Description Contact Information
NCT02329327 Cornell "A Study in Patients with Acute Major Bleeding to Evaluate the Ability of Andexanet Alfa to Revers the Anticoagulation Effect of Direct and Indirect Oral Anticoagulants (ANNEXA-4)" Robin Ashford: 304-691-1082
NCT01442194 Ferguson "Long-term, Prosepctive, Multi- national, parallel-cohort study Monitoring Safety in Patients with MS Newly Started with Fingolimod Once Daily or Treated with Another Approved Disease- Modifying Therapy" CLR1104 Linda Morgan: 304-691-1213
NCT02239120 Nolte "Dabigatran Etexilate for Secondary Stroke Prevention in Patients With Embolic Stroke of Undetermined Source (RE-SPECT ESUS)" Melissa Marcum: 304-691-8560

Rebecca Smith: 304-691-1834
NCT02477618 Shah "A Randomized, Double-Blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of SAGE547 Injection in the Treatment of Subjects with Super Refrac-tory Status Epilepticus" Robin Ashford: 304-691-1082

Doug Melton: 304-691-8618
NCT01797185 Ferguson "Open-label, safety study of SPARC1104 in Subjects with Spasticity due to MS" Linda Morgan: 304-691-1213
NCT02373904 Cheung "A Prospective, Multi-Center Study of the IlluminOSS Photodynamic Bone Sta-bilization System for the Treatment of Impending and Actual Pathological Fractures in the Humerus from Metastatic Bone Disease" Linda Morgan: 304-691-1213
NCT03114657 Neitch "A Phase III, Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Efficacy and Safety Study of Crenezumab in Patients with Prodromal to Mild Alzheimer's Disease" Melissa Marcum: 304-691-8560
NCT02792218 Ferguson "A Randomized, Double-Blind, Double-Dummy, Parallel-Group Study Comparing the Efficacy and Safety of Ofatumumab versus Teriflunomide in Patients with Relapsing Multiple Sclerosis" Linda Morgan: 304-691-1213

Doug Melton: 304-691-8618
NCT02878330 Lambros "A Phase 2B Randomized, Double-Blind Placebo-Controlled Study to Evaluate the Safety and Efficacy of MEDI8897, a Mono-clonal Antibody with an Extended Half-Life Against Respiratory Synctial Virus, in Healthy Preterm Infants" Robin Ashford: 304-691-1082