i2b2 (Informatics for Integrating Biology and the Bedside) is an NIH-supported National Center for Biomedical Computing that developed a scalable informatics framework designed for translational research. The i2b2 framework is based on the Research Patient Data Registry (RPDR) developed at Massachusetts General Hospital. If you would like more information on how to use i2b2 as part of the Appalachian Clinical and Translational Science Institute, please contact Alfred Cecchetti in Health Informatics.